Berberine is a naturally occurring alkaloid and a primary constituent of several plants including barberry, goldenseal and phellodendron. Recent studies indicate that berberine is a helpful supplement for maintaining cardiometabolic health and is considered safe and effective. Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. In vivo and in vitro experiments have also shown blood pressure support and vasorelaxatory effects of berberine. It seems that berberine acts on both the endothelium and the underlying vascular smooth muscle to induce vasorelaxation via multiple cellular mechanisms. Berberine has been used for thousands of years in traditional Chinese and Ayurvedic medicine to provide antioxidant activity, immune system support and proper microbial balance. A highly bioavailable form of Folate (glucosamine salt of (6S)-5-methyltetrahydrofolate), is structurally analogous to the reduced and active form of folic acid.